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Risk Factors for Immunological Responses Against Injectable DDS
Risk Factors for Immunological Responses Against Injectable DDS
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Immunological Reactions Against Injectable DDS and their Clinical Consequences
Immunological Reactions Against Injectable DDS and their Clinical Consequences
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Relative Risk of Immunogenicity for Several Antigen Categories
Relative Risk of Immunogenicity for Several Antigen Categories
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Simplified schematic presentation of the interrelationship between the...
Simplified schematic presentation of the interrelationship between the immunological reactions discussed in the text. The dashed arrows represent possible, not yet confirmed pathways for platelet...
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Schematic illustration of the interaction of molecules (orange bullets,...
Schematic illustration of the interaction of molecules (orange bullets, which can be drugs, targeting ligands, or repeat units of a polymer) with B cell receptors (BCRs, surface immunoglobulins on B...
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The quantification of host cell protein contained in different copy and...
The quantification of host cell protein contained in different copy and control rhEPO products.
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Bars represent the areas under the curve (R-AUC) of the HMW, distinct dimer...
Bars represent the areas under the curve (R-AUC) of the HMW, distinct dimer and rhEPO/HSA peaks relative to the total AUC for each product.
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AF4 elugrams of (a) Epogen® and different rhEPO copy products from (b) China...
AF4 elugrams of (a) Epogen® and different rhEPO copy products from (b) China and India, (c) Korea and (d) Latin America using UV detection at 280 nm. In all rhEPO copy products and Epogen®, the dimer...
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Bars represent the areas under the curve (R-AUC) of the HMW, dimer and...
Bars represent the areas under the curve (R-AUC) of the HMW, dimer and rhEPO/HSA peaks relative to the total AUC for each product.
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HP-SEC chromatograms of (a) HSA, EPO-BRP and Epogen®, and different rhEPO...
HP-SEC chromatograms of (a) HSA, EPO-BRP and Epogen®, and different rhEPO copy products from (b) China and India, (c) Korea and (d) Latin America, using UV detection at 280 nm. In all copy products...
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Performance of various rhEPO copy products on SDS-PAGE (2 IU/lane) detected...
Performance of various rhEPO copy products on SDS-PAGE (2 IU/lane) detected with Western blot using anti-HSA antibody under (a) non-reducing and (b) reducing condition.
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Performance of various rhEPO copy products on SDS-PAGE (2 IU/lane) detected...
Performance of various rhEPO copy products on SDS-PAGE (2 IU/lane) detected with Western blot using anti-EPO antibody under (a) non-reducing and (b) reducing condition.
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SDS-PAGE gel of different rhEPO copy products (2 IU/lane) stained with...
SDS-PAGE gel of different rhEPO copy products (2 IU/lane) stained with SilverQuest™ Silver Staining under (a) non-reducing conditions and (b) reducing conditions. Arrows indicate the expected...
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Technical Challenges for Developing Sustained-Release Protein Dosage Forms
Technical Challenges for Developing Sustained-Release Protein Dosage Forms
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Schematic description of protein aggregation and adsorption
Schematic description of protein aggregation and adsorption
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Origin and Declared Potency of Copy rhEPO Alpha Products Used in the Current...
Origin and Declared Potency of Copy rhEPO Alpha Products Used in the Current Study. One Batch per Product was Used
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Increased numbers of pro-inflammatory IFN-γ producing human FVIIa-specific...
Increased numbers of pro-inflammatory IFN-γ producing human FVIIa-specific CD4+ T cells in human FVII-transgenic mice after treatment with human FVIIa and LPS. Human FVII-transgenic mice were treated...
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Break of immune tolerance to human FVIIa in human FVII-transgenic mice is...
Break of immune tolerance to human FVIIa in human FVII-transgenic mice is not due to structural alterations of FVIIa induced by mixing with LPS. (a) Human FVIIa HPLC-SEC analysis was done with human...
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Break of immune tolerance against human FVIIa in human FVII-transgenic mice...
Break of immune tolerance against human FVIIa in human FVII-transgenic mice is not isotypically restricted. Human FVII-transgenic mice were treated with a mixture of 10 μg human FVIIa and 2 μg of LPS...
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Immune tolerance to human FVIIa in human FVII-transgenic mice breaks down...
Immune tolerance to human FVIIa in human FVII-transgenic mice breaks down when human FVIIa is given with a concomitant stimulation of the innate immune system. (a) Human FVII-transgenic mice and...
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Human FVII-transgenic mice are immune tolerant to human FVIIa and otherwise...
Human FVII-transgenic mice are immune tolerant to human FVIIa and otherwise fully immune competent. (a) Human FVII-transgenic (huFVIItg) mice (Black circle) and C57BL/6 control mice (Black triangle)...
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Human F7 is mainly expressed in the liver of adult animals and shows high...
Human F7 is mainly expressed in the liver of adult animals and shows high expression levels in the neonatal thymus of human FVII-transgenic mice. (a) Two-step reverse transcription PCR analysis of...
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Human F7 cDNA is correctly integrated into the murine hprt locus. a...
Human F7 cDNA is correctly integrated into the murine hprt locus. a Schematic representation of the integrated human F7 construct consisting of the murine albumin promoter, human F7 cDNA, a 2.1 kb...
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Summary of Reported Structural and Biological Consequences of Oxidation of...
Summary of Reported Structural and Biological Consequences of Oxidation of Protein and Peptide Therapeutics
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Summary of Adverse Events a in Baxter Trials in Subjects Who Developed...
Summary of Adverse Events a in Baxter Trials in Subjects Who Developed Anti-rHuPH20 Antibodies
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Prevalence and Incidence of rHuPH20-Binding Antibodies in All Clinical Trials
Prevalence and Incidence of rHuPH20-Binding Antibodies in All Clinical Trials
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Correlation Analysis of the Response of THP-1 and Primary Monocytes
Correlation Analysis of the Response of THP-1 and Primary Monocytes
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Linear Combinations of Cytokine Concentrations in Primary Monocytes and...
Linear Combinations of Cytokine Concentrations in Primary Monocytes and THP-1 Cells
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Structural Changes in Aggregated IGIV Samples
Structural Changes in Aggregated IGIV Samples
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Percentage, Particle Size and Distribution of IGIV Aggregates in Unstressed...
Percentage, Particle Size and Distribution of IGIV Aggregates in Unstressed and Stressed Samples
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Expression of innate immunity receptors on the surface of THP-1 cells....
Expression of innate immunity receptors on the surface of THP-1 cells. x-axes represent the fluorescence intensity measured by flow cytometry using the appropriate channel for the fluorescent dye on...
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Dose-response of THP-1 cells to stirring-induced IGIV aggregates. (a-e)...
Dose-response of THP-1 cells to stirring-induced IGIV aggregates. (a-e) individual cytokine response to aggregates in THP-1 cells. Bars represent 1 standard deviation of the mean response of cell...
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Dose-response of primary monocytes to stirring-induced IGIV aggregates....
Dose-response of primary monocytes to stirring-induced IGIV aggregates. (a-e) individual cytokines response to aggregates in primary monocytes. Bars represent 1 standard deviation of the mean response...
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